Electric Literature of 41680-34-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41680-34-6, name is 3-Amino-1H-pyrazole-4-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 5-amino-i H-pyrazole-4-carboxylic acid (1 .00 g, 7.87 mmol) and ethyl 2-formyl-3- oxopropanoate (2.0 ml, 16 mmol) in acetic acid (6.0 ml) was heated for 1 h at 1100 in a microwave reactor (Biotage Initator). Upon cooling to room temperature, the precipitate wascollected by filtration, washed with water and dried under high vacuum at SOC to give the title compound (900 mg, 48% yield).[C-MS (Method 1): R = 0.68 mm; MS (ESIpos): m/z = 236.1 [M+i]iH-NMR (400 MHz, DMSO-d6): 6 [ppm] = 12.59 (5, iH), 9.72 (d, iH), 9.13 (d, iH), 8.76 (5, 1 H), 4.41 (q, 2H), 1.38 (t, 3H).
The synthetic route of 3-Amino-1H-pyrazole-4-carboxylic acid has been constantly updated, and we look forward to future research findings.