Synthetic Route of 368870-03-5, A common heterocyclic compound, 368870-03-5, name is (4-(1H-Pyrazol-1-yl)phenyl)methanamine, molecular formula is C10H11N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 212-[4-((E)-2-Cyano-ethenesulfonyl)-phenyl]-N-(4-pyrazol- l-yl-benzyl)-isobutyramide 2-[4-((E)-2-Cyano-ethenesulfonyl)-phenyl]-2-methyl-propionic acid (75.0 mg, 0.268 mmol), 4-Pyrazol-l-yl-benzylamine (46.5 mg, 0.268 mmol), N-(3-dimethylaminopropyl)- N’-ethylcarbodiimide hydrochloride (51.5 mg, 0.268 mmol) and 1-hydroxybenzotriazole (18.1 mg, 0.134 mmol) were dissolved in methylene chloride (7.50 mL) and the reaction mixture was allowed to stir overnight at room temperature. The reaction was concentrated under reduced pressure and the residue was taken up in 1.2 mL of acetonitrile. Purification by mass-directed HPLC using a gradient of 25-75% MeCN/water both containing 0.1% TFA as the eluting solvent to afford 2-[4-((E)-2-Cyano-ethenesulfonyl)-phenyl]-N-(4- pyrazol- l-yl-benzyl)-isobutyramide trifluoroacetic acid salt as a pale -yellow solid (33 mg,28%), mp = 47-53 C. MS: 435 (M+H); 1H-NMR (CDC13, 400 MHz) delta 7.92-7.83 (m, 3H), 7.80-7.76 (m, 1H), 7.64-7.57 (m, 4H), 7.30-7.25 (m, 2H), 7.21 (d, 1H, J = 15.6 Hz), 6.55 (d, 1H, J = 15.6 Hz), 6.52-6.47 (m, 1H), 5.73-5.63 (m, 1H), 4.44 (d, 2H, J = 5.7 Hz), 1.64 (s, 6H).
The synthetic route of 368870-03-5 has been constantly updated, and we look forward to future research findings.