Simple exploration of 1-Methyl-1H-pyrazole-5-carboxylic acid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Related Products of 16034-46-1, The chemical industry reduces the impact on the environment during synthesis 16034-46-1, name is 1-Methyl-1H-pyrazole-5-carboxylic acid, I believe this compound will play a more active role in future production and life.

General procedure: The appropriate carboxylic acid (34.2 lmol, 2 eq), EDCIHCl(5.30 mg, 34.2 lmol, 2 eq) and DMAP (17.1 lmol, 1 eq) were combinedin CH2Cl2 (2 mL) and stirred at RT for 10 min. Amine 15(10.0 mg, 17.1 lmol, 1 eq) was added and the resulting mixturestirred at RT overnight. Reaction was, quenched by the additionof saturated aqueous NH4Cl solution (5 mL), extracted with EtOAc(3 5 mL) and the combined organic layers washed with 0.1 Maqueous KOH solution, brine, dried (MgSO4), filtered and concentratedin vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-5-carboxylic acid, other downstream synthetic routes, hurry up and to see.