Introduction of a new synthetic route about 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde

The chemical industry reduces the impact on the environment during synthesis 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde. I believe this compound will play a more active role in future production and life.

Related Products of 25016-12-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25016-12-0, name is 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3′-chloro-3,4,5,6-tetrahydro-2H-[l,2′]bipyrazinyl (3 g, 15.1 mmol, 1 eq) and l,3-dimethyl-lH-pyrazole-4-carbaldehyde (2.0 g, 16.6 mmol, 1.1 eq) in DCE (75 mL) add sodium triacetoxyborohydride (4.8 g, 22.6 mmol, 1.5 eq) and stir at room temperature over the weekend. Add 2 N sodium hydroxide (100 mL), separate the layers, extract the aqueous layer twice with DCM (75 mL), dry (magnesium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 0: 100 to 10:90 –65-methanol:DCM). Combine only the fractions which contain the main component and concentrate to give the title preparation as a viscous yellow oil (2.14 g, 46%). Combine all other fractions which contain main component plus impurities, concentrate then repeat the chromatography step to recover further material (1.6 g, 35%, total yield 81%). MS (ES): m/z = 307.1 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 1,3-Dimethyl-1H-pyrazole-4-carbaldehyde. I believe this compound will play a more active role in future production and life.