These common heterocyclic compound, 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H8N2O
At room temperature, add 1,3-dimethyl-1H-pyrazole-5-ol (1.12 g, 0.01 mol),(3.95 g, 0.05 mol) pyridine was sequentially dissolved in 20 ml of dichloromethane. The low temperature bath was cooled to 3 C.To the above mixture, 7-chloro-3-(methylsulfonyl)quinoline-8-carbonyl chloride (6.08 g, 0.02 mol) was added dropwise at a dropping rate of 2 drops per 30 seconds.After the dropwise addition was completed, the mixture was naturally warmed to room temperature and reacted for 5 hours. To the reaction mixture was added 10 ml of a saturated aqueous sodium hydrogen carbonate solution, and dichloromethane (3 * 15 ml) was extracted. The organic layers were combined, washed with water (1 * 15 ml), washed with saturated brine, and dried over anhydrous magnesium sulfate.The product was desolvated under reduced pressure to obtain 3.03 g of the product with a yield of 80%.
The synthetic route of 1,3-Dimethyl-1H-pyrazol-5-ol has been constantly updated, and we look forward to future research findings.