Adding a certain compound to certain chemical reactions, such as: 83-10-3, name is 1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83-10-3, Product Details of 83-10-3
Step 1 ) N-(3-fluoro-4-hvdroxyphenyl)- 1 ,5-dimethyl-3 -oxo-2-phenyl-2,3 -dihydro- 1H- pyrazole-4- carboxamide [0193] To a suspension of 4-amino-2-fluorophenol (2.54 g, 20 mmol) and 1,5- dimethyl-3 -oxo-2- phenyl-2,3 -dihydro- lH-pyrazole-4-carboxylic acid (4.74 g, 20.4 mmol) in DCM (60 mL) were added EDCI (4.6 g, 24 mmol) and HOAT (0.54 g, 4 mmol). The reaction was stirred at 45 C for 12 hours, then cool to rt, quenched with H20 (10 mL), and stirred for another 4 hours. The solid was obtained by filtration and washed with DCM (20 mL x 3), then dried at 60 C in vacuo for 12 hours to give the title compound as a pale yellow solid (6.37 g, 93.4%). MS (ESI, pos. ion) m/z: 342.1 [M+H]+; NMR (400 MHz, DMSO-i): delta (ppm) 10.59 (s, 1H), 9.58 (s, 1H), 7.64 (dd, J= 2.4 Hz, 13.5 Hz, 1H), 7.60 (m, 2H), 7.50 (m, 1H), 7.42 (m, 2H), 6.97 (m, 1H), 6.88 (dd, J= 9.6 Hz, 8.8 Hz, 1H), 3.34 (s, 3H), 2.70 (s, 3H).
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