The important role of 1H-Pyrazole-3,5-dicarboxylic acid

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Adding a certain compound to certain chemical reactions, such as: 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3112-31-0, Product Details of 3112-31-0

(2R,4R)-4-Amino-5-biphenyl-4-yl-2-hydroxypentanoic acid butyl ester (HCl salt; 108 mg, 286 mummol, 1.0 eq.), 3,5-pyrazoledicarboxylic acid (66.9 mg, 429 mumol, 1.5 eq.), and HATU (160 mg, 430 mumol, 1.5 eq.) were combined in DMF (5 mL), and the resulting mixture was stirred for 2 minutes. DIPEA (150 muL) was added and the mixture was stirred for 1 hour. The mixture was dried under vacuum, and the product was purified using reverse phase chromatography to yield the title compound as a TFA salt (60 mg; purity 98percent). MS m/z [M+H]+ calc’d for C26H29N3O6, 480.21. found 480.4).

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