Reference of 1310350-99-2, A common heterocyclic compound, 1310350-99-2, name is 4-Chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid, molecular formula is C5H3ClF2N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 196 N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxamide The title compound was synthesized by procedures and steps analogous to those described in Method Z, Example 186 above, but using 4-chloro-1-(difluoromethyl)-1H-pyrazole-3-carboxylic acid (WO201169934). MS m/z=488.1 [M+H]+. Calculated for C17H13ClF7N5O2: 487.76 1H NMR (400 MHz, CHLOROFORM-d) delta=8.57 (br. s., 1H), 8.12-8.04 (m, 1H), 7.93 (s, 1H), 7.31-6.99 (t, 1H), 6.99-6.95 (m, 1H), 4.06 (m, 1H), 2.80 (dd, J=2.2, 13.7 Hz, 1H), 1.92 (t, J=13.1 Hz, 1H), 1.65 (s, 3H)
The synthetic route of 1310350-99-2 has been constantly updated, and we look forward to future research findings.