Application of 13808-64-5, A common heterocyclic compound, 13808-64-5, name is 4-Bromo-3-methylpyrazole, molecular formula is C4H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of NaH (60%, 2.5 g, 62.9 mmol) in THF (800 mL), was dropwise added 4-bromo-3-methyl-lH-pyrazole (10 g, 62.9 mmol) in 100 ml THF at 0 C. After stirred at the same temperature for 30 min, BnBr (4.4 ml, 62.9 mmol) was added at 0 C. The reaction mixture was stirred at 15 C for 1 h and carefully quenched with ice-water. The resulting mixture was extracted with EtOAc (2×150 mL). The combined organic layers were washed with brine (2x 100 mL), dried over anhydrous Na2S04 and then concentrated. The residue was purified by silica gel chromatography (PE/EtOAc =4/1 to 1/1) to give the title compound (6 g, yield : 60%); m/z (ES+) : 251 [M+H]+.
The synthetic route of 13808-64-5 has been constantly updated, and we look forward to future research findings.