Synthetic Route of 13808-64-5,Some common heterocyclic compound, 13808-64-5, name is 4-Bromo-3-methylpyrazole, molecular formula is C4H5BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 4-bromo-3 -methyl- lH-pyrazole 1 (161 mg, 1 mmol) in pyridine (1 mL) was added 2,5-difluorophenyl boronic acid (240 mg, 1.5 mmol), and 4A molecular sieves. The mixture was stirred for 72 h at room temperature. The reaction was worked-up with saturated NaHC03and EtOAc extraction. The organic layer was separated and aqueous was extracted with EtOAc. The combined organic phase was dried over a2S04, filtered, and concentrated to give crude product. The crude product was purified on ISCO columns. Fractions containing pure product were combined and evaporated to give 43 (100 mg, 37%) as a blue wax.
The synthetic route of 13808-64-5 has been constantly updated, and we look forward to future research findings.