Synthetic Route of 16617-46-2, These common heterocyclic compound, 16617-46-2, name is 3-Amino-1H-pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of ethyl 3-(3,4-dichlorophenyl)-3-oxopropanoate (1.2 g, 4.60 mmol, 1.20 equiv), 5-amino-lH-pyrazole-4-carbonitrile (400 mg, 3.70 mmol, 1.00 equiv), butan-l-ol (1 mL), and TsOH (10 mg, 0.06 mmol, 0.05 equiv) was stirred for 1 h at 130°C. The reaction progress was monitored by LCMS. The solids were collected by filtration. The solid was washed with 3×1 mL of methanol. This resulted in 0.8 g (71percent) of 5-(3,4-dichlorophenyl)-7-oxo-4H,7H-pyrazolo[l,5-a]pyrimidine-3- carbonitrile as a white solid. *H NMR (300 MHz, DMSO): delta 8.44 (s, 1H), 8.17 (s, 1H), 7.85 (s, 1H), 6.37 (s, 1H)
Statistics shows that 3-Amino-1H-pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 16617-46-2.