Electric Literature of 37622-90-5, The chemical industry reduces the impact on the environment during synthesis 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, I believe this compound will play a more active role in future production and life.
Polymer-supported triphenylphospine (3.0mmol/g, 3 equiv, 1.0g) was swollen inTH F /dichloromethane (1: 1, 1 OOmls) under a nitrogen atmosphere. Ethyl 1 H-pyrazole-4-carboxylate (500mg, 3.57mmol) and 4-(chloromethyl)benzyl alcohol (671mg, 4.28mmol) were30 added followed by a solution of diisopropyl azodicarboxylate (1.08g, 5.35mmol) inTHF/dichloromethane (1: 1, 1 Omls) over a period of 30m ins. The reaction mixture was stirred at room temperature for 18 hours, the mixture was filtered through celite and the resin waswashed with 3 cycles of dichloromethane/methanol (1Smls). The combined filtrates wereevaporated in vacuo and triturated with ethanol to give a white solid identified as 1-(4-chloromethyl-benzyl)-1 H-pyrazole-4-carboxylic acid ethyl ester (7 41 mg, 2 .66m mol, 7S%).S [M+Hr = 279.0S
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-pyrazolecarboxylate, other downstream synthetic routes, hurry up and to see.