Related Products of 121507-34-4, A common heterocyclic compound, 121507-34-4, name is 5-Isopropoxy-1H-pyrazol-3-amine, molecular formula is C6H11N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 2,3,6-tf chloro-5-nitropyridine (2.61 g, 11.4 mmol) and DIEA (1.90 ml, 11.4 mmol) in TEtaF (50 ml) was added the 5-isopropoxy-lH-pyrazol-3-amine (1.20 g, 8.50 mmol) at 0 0C. After addition, the reaction mixture was stirred at 25 0C for 5 days. The solvent was removed under reduced pressure and the resulting residue was purified by column chromatography (hexane-EtOAc = 2.5 : 1) to give the title compound as a yellow solid (0.77 g, 27%). 1H NMR (400 MHz) delta 12.26 & 11.64 (s, IH), 10.42 & 10.04 (s, IH), 8.81 & 8.77 (s, EPO
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.