Reference of 31230-17-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixtureof 2, 4,6-trichloropyrimidine (1.00 g, 5. 46 mmol),3-amino-5-methyl-lH- pyrazole (530 mg, 5.46 mmol) and triethylamine (1.1 ml,8. 2 mmol) inEtOH (10 ml) was stirred at room temperature for 1 day. Solvent was removed and the mixture was partitioned between EtOAc and water. The organic layer was concentrated to give the desired product (1.34 g,quantitative). lH NMR (CDC13) :6 2.30(m, 3 H), 5.90 (m, 1 H), 7.85 (m, 1 H), 8.50 (br s,1 H).
The synthetic route of 5-Methyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.