Reference of 14521-80-3,Some common heterocyclic compound, 14521-80-3, name is 3-Bromo-1H-pyrazole, molecular formula is C3H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 5. Synthesis of N-[3-({4-[2-(3-bromo-lH-pyrazol-l-yl)-l,l,l,3,3,3-hexafluoropropan~ 2-yl]-2,6-dimethylphenyl}carbamoyl)phenyl]-2-chloropyridine-3-carboxamide.; 2-(4- { [(3 – { [(2-chloropyridin-3 -yl)carbonyl]amino } phenyl)carbonyl]amino } -3 ,5 -dimethylphenyl)- 1 ,l,l,3,3,3-hexafluoro-2-yl methanesulfonate (0.10 g) and 3-bromopyridine (28 mg) were dissolved in DMF (1.5 ml), and sodium hydride (in oil, 10 mg) was added thereto under ice cooling. After stirring for 4 hours, water was added. The resulting mixture was extracted with ethyl acetate, washed with water, and dried over magnesium sulfate. After the filtration, the solvent was evaporated off under reduced pressure. The resulting residue was purified with silica gel chromatography to obtain the title compound (76 mg, 70%).1H-NMR (CDCl3) delta : 2.31(6H, s), 6.45 (IH, d), 7.16 (2H, s), 7.36-7.64 (4H, m), 7.74 (IH, d), 7.86 (IH, d), 8.14-8.22 (IH, m), 8.29 (IH, s), 8.44-8.55 (2H, m).
The synthetic route of 14521-80-3 has been constantly updated, and we look forward to future research findings.