Synthetic Route of 330792-70-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of 5-amino-3-(4-phenoxyphenyl)- 1H-pyrazole- 4-carbonitrile (20 g, 1.0 eq) and Cs2CO3 (70.7 g, 3.0 eq) in 300 mL dry DMF at 60°C was added (S)-tert-butyl 3-(tosyloxy)piperidine-1-carboxylate (31 g, 1.2 eq) slowly. After addition was completed, the reaction mixture was stirred at 60 °C for 40 hours. Water was added and the mixture was extracted with EtOAc. The organic extract was washed with water and brine, dried with anhydrous Na2SO4, and purified by flash chromatography to give compound 7 as a white solid (8.8 g, 27percent). ?H NMR (400 MHz, CDC13) oe 7.85-7.88 (m, 2H), 7.33-7.37 (m, 2H), 7.09-7.14 (m, 1H), 7.03-7.06 (m, 4H), 4.52 (brs, 2H), 4.19-4.29 (m, 1H), 4.01-4.18 (m, 1H), 3.80-3.89 (m, 1H), 3.02-3.19 (m, 1H), 2.81 (t, J = 12.8 Hz, 1H), 2.20-2.31 (m, 1H), 2.07-2.18 (m, 1H),1.83-1.92 (m, 1H), 1.76-1.81 (m, 1H), 1.44 (s, 9H).
The synthetic route of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.