Application of 5071-61-4, The chemical industry reduces the impact on the environment during synthesis 5071-61-4, name is 5-Phenyl-1H-pyrazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.
5-Phenyl-1H-pyrazole-3-carboxylic acid (purchased from PharamCore, http://www.pharmacore.com; 197 mg, 1.03 mmol) and benzyl alcohol (131 mL, 1.24 mmol) were dissolved in 5 mL of acetonitrile and treated with EDC (393 mg, 2.05 mmol) and DMAP (376 mg, 3.08 mmol). The resulting solution was stirred for 12 h at room temperature. The reaction mixture was diluted with CH2Cl2, washed with 10% aqueous NaHCO3 solution (2x), water and 5% acetic acid solution (2x). The organic phase was collected, dried over Na2SO4, filtered and then concentrated in vacuo. Crude material obtained was purified by silica gel column chromatography with a 25% ethyl acetate : CH2Cl2 solvent system to give 189 mg (66%) of 6 as a white solid. Mp 151-152oC; 1H NMR (300 MHz, CDCl3) 7.68 (2 H, d, J = 6.71 Hz), 7.40-7.27 (8 H, m), 7.02 (1 H, s), 5.22 (2 H, s); 13C NMR (126 MHz, CDCl3) d . 160.79, 148.95, 139.13, 135.52, 130.59, 129.09, 128.78, 128.61 (two carbons), 128.56, 125.86, 105.78, 67.02. HRMS (EI), M+1 calcd. for C17H15N2O2, 279.1128; found 279.1145. HPLC tR = 4.3 min.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Phenyl-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.