Synthetic Route of 1126-00-7, The chemical industry reduces the impact on the environment during synthesis 1126-00-7, name is 1-Phenylpyrazole, I believe this compound will play a more active role in future production and life.
EXAMPLE 29A 4-Bromo-1-phenyl-1H-pyrazole To 1-phenylpyrazole (Aldrich, 1 g, 6.94 mmol) in 10 mL acetic acid was added 1.1 g of Br2 (Fisher, 6.94 mmol) in 10 mL acetic acid. This mixture was warmed to 100 C. in a pressure tube for 8 h. The material was cooled to ambient temperature, poured into ice and H2O in a 500 mL beaker and excess saturated, aqueous NaHCO3 was added until all the acetic acid had been quenched. EtOAc (50 mL) was added and the layers were separated. The aqueous layer was extracted 2*15 mL EtOAc and the combined organics were dried over Na2SO4 and concentrated under reduced pressure to give a crude solid. Purification via flash column chromatography (SiO2, 50% hexanes-EtOAc) gave 1.5 g of the title compound (6.72 mmol, 97% yield). MS (DCI/NH3) m/z 223, 225 (M+H)+.
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