Adding a certain compound to certain chemical reactions, such as: 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39806-90-1, name: 4-Iodo-1-methyl-1H-pyrazole
g) Preparation of [0254] [0255] To a mixture of 4-iodo-1-methyl-1H-pyrazole (0.003 mol) and Cs2CO3 (1 g) was added 10 ml dioxane. The mixture was degassed by applying alternating N2 atmosphere and vacuum. Intermediate (66) (0.0022 mol) was added in 10 ml dioxane, and degassed as above. Pd2(dba)3 (0.1 g) and Xantphos (0.13 g) were added, degassed again, and the reaction mixture was stirred under a N2-atmosphere at 100 C. overnight. The reaction mixture was cooled, 150 ml water added, and extracted with 2 times with 150 ml of DCM. The combined organic layer was dried (MgSO4), filtered, and evaporated. The residue was purified by HPLC (HPLC method A). The residue was crystallized from DIPE, yielding 0.195 g of intermediate (67).
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