Electric Literature of 66121-71-9, These common heterocyclic compound, 66121-71-9, name is 4-Cyano-1-methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
dissolved in Et2O (30 mL) and was added, and the the solution stirred for 30 min. 1 -Methyl- lH-pyrazole-4-carbonitrile (1 g, 9.34 mmol) was added in Et2O (20 mL) at -78 0C and the reaction was allowed to warm to room temperature over 1 h, then MeOH (10 mL) containing ammonium acetate (0.720 g, 9.34 mmol) was added. The solvents were evaporated and the residue taken up in DCM and water. The organic layer was separated and the aqueous phase extracted with DCM. The combined organic phases were shaken with Brine and dried over MgSO4, filtered and the solvent evaporated to give the product (1.4 g, 68% yield): MS (ES) m/z 220 [M+l]+.
Statistics shows that 4-Cyano-1-methylpyrazole is playing an increasingly important role. we look forward to future research findings about 66121-71-9.