Electric Literature of 1369959-12-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1369959-12-5, name is 3-Chloro-5-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of 3-methyl-5-nitro-lH-pyrazole (2.46 g, 19.40 mmol) and l -methyl-4- piperidinemethanol (5.00 g, 38.70 mmol) in dry Me-THF (190 mL). Di-tert-butyl azodicarboxylate (8.91 g, 38.70 mmol) and PPh3 (10.20 g, 38.70 mmol) were added. The solution was heated at 55 C over the weekend. The reaction mixture was diluted with EtOAc and water. The organic layer was separated and the aqueous layer was extracted thrice with EtOAc. The organic layers were combined, washed with brine, dried over MgS04, filtered and concentrated. The residue (yellow oil) was purified by column chromatography on silica gel (Irregular SiOH, 15-40 muiotaeta, 330 g, liquid loading in DCM, mobile phase: DCM/MeOH, gradient from 100:0 to 90: 10). The fractions containing the product were combined and evaporated to dryness to give 2.36 g of intermediate 195 (51% yield, yellow oil).
The chemical industry reduces the impact on the environment during synthesis 3-Chloro-5-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.