Synthetic Route of 31230-17-8,Some common heterocyclic compound, 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1) Weigh 2,4,6-trichloropyrimidine (1.83 g, 10 mmol)And 3-amino-5-methylpyrazole (0.97 g, 10 mmol) dissolved in 100 mL of absolute ethanol,Add triethylamine (2.7 mL, 20 mmol), and stir the reaction at 0 C for 12 h;2) After stopping the reaction,Add 150 mL of water to the reaction solution.A large amount of white solid was precipitated immediately.Filtering,The solid was washed sequentially with 50 mL of ice water and 20 mL of ice methanol.After drying, Intermediate 1 (1.82 g, yield 75%) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methyl-1H-pyrazol-3-amine, its application will become more common.