Synthetic Route of 17635-45-9, These common heterocyclic compound, 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 11-a (79 mg, 0.50 mmol) and compound 5 (70 mg, 0.17 mmol) were dissolved in n-butanol (2 mL), p-toluene sulfonic acid monohydrate (95 mg, 0.50 mmol) was added. The mixture was heated to 110¡ã C. and stirred for 16 hours. After cooled to room temperature, the mixture was stirred for further 30 minutes, and there was solid precipitated. After filtration, the solid was purified by preparation HPLC (mobile phase:acetonitrile, water (0.05percent trifluoroacetic acid); gradient: 60percent-90percent-10percent) to give yellow solid T-11 (31 mg, yield: 34percent). LC-MS (ESI): m/z=546 [M+H]+. (0169) 1H-NMR (400 MHz, CDCl3) delta: 8.49 (s, 1H), 8.40 (s, 1H), 7.94 (d, J=6 Hz, 1H), 7.91 (d, J=2 Hz, 1H), 7.84 (d, J=9 Hz, 2H), 7.687.73 (m, 3H), 7.40 (d, J=6 Hz, 2H), 6.47 (t, J=2 Hz, 1H), 4.65 (d, J=9 Hz, 2H), 4.26 (d, J=9 Hz, 2H), 3.43 (s, 2H), 3.10 (q, J=6 Hz, 2H), 1.43 (t, J=6 Hz, 3H) ppm
Statistics shows that 4-Pyrazol-1-yl-phenylamine is playing an increasingly important role. we look forward to future research findings about 17635-45-9.