Continuously updated synthesis method about 3-Chloro-1H-pyrazol-4-amine hydrochloride

The chemical industry reduces the impact on the environment during synthesis 3-Chloro-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.

Related Products of 63680-90-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 63680-90-0, name is 3-Chloro-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.

10022] A 100 mE, 3-neck flask was charged with 3-chloro-1H-pyrazol-4-amine hydrochloride (5.00 g, 32.5 mmol), tetrahydrofuran (25 mE) and water (25 mE). The resulting suspension was cooled to 5C. and sodium bicarbonate (10.9 g, 130 mmol) was added, followed by dropwise addition of3-((3,3,3,-trifluoropropyl)thio)propanoyl chloride (7.52 g,34.1 mmol) at <5 C. The reaction was stirred at <10 C. for1 hour, at which point thin layer chromatography analysis (Eluent: 1:1 ethyl acetate/hexane) indicated the starting material was consumed and the desired product was formed. The reaction mixture was diluted with ethyl acetate (25 mE) and water (25 mE). The layers were separated and the aqueous layer was extracted with ethyl acetate (3x25 mE). The organic layers were combined and concentrated to dryness. The residue was suspended in 2:1 methyl tert-butylether/heptanes (30 mE), stirred for 1 hour and filtered. The solid was rinsed with 2:1 methyl tert-butylether/heptanes (20 mE) and further dried under vacuum at room temperature (about 22 C.) to afford a white solid (7.80 g, 80%): mp 83-85 C.; ?H NMR (400 MHz, DMSO-d5) oe 12.90 (s, 1H), 9.59 (s, 1H), 8.02 (s, 1H), 2.82 (t, J=7.2 Hz, 2H), 2.76-2.69 (m, 2H), 2.66 (t, J=7.1 Hz, 2H), 2.62-2.48 (m, 2H); ?3C NMR (101 MHz, DMSO-d5) oe 168.97, 129.95, 126.60 (q, J=277.4 Hz), 123.42, 116.60, 35.23,33.45 (q, J=27.3 Hz), 26.85, 23.03 (q, J=3.4 Hz); ElMS mlz301 ([M]j. The chemical industry reduces the impact on the environment during synthesis 3-Chloro-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.