New learning discoveries about 3-Nitro-1H-pyrazole

Adding a certain compound to certain chemical reactions, such as: 26621-44-3, name is 3-Nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26621-44-3, SDS of cas: 26621-44-3

3-Nitro-lH-pyrazole (3 g, 26.5 mmol’, 1 eq) , l-chloro-3- methylbut-2-ene (4.16 g 39.8 mmol, 1.5 eq) , potassium iodide (5 mg, 0.03 mmol, 0.001 eq. ) , and cesium carbonate (17.2 g, 53 mmol, 2 eq) were mixed in 1,4-dioxane (305 ml) . The mixture was subjected to microwave irradiation at 1200C for 30 min. The mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo. The residue was purified with silica gel column chromatography using 0 to 40% ethyl acetate in hexane as an eluent to give 4.18 g of the title compound (87%) as a brown oil. [M+H] calc’d for C8HnN3O2, 182 found, 182.

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