Related Products of 5334-28-1,Some common heterocyclic compound, 5334-28-1, name is 5-Amino-1-(4-bromophenyl)-1H-pyrazole-4-carbonitrile, molecular formula is C10H7BrN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A suspension of the appropriate derivatives 2a-d or 9(0.001 mol) was dissolved in glacial acetic acid (3 mL) then POCl3(0.2 mL) was added quickly. The reaction mixture was refluxedfor 2 h (the reaction system was carefully observed by TLC). Aftercooling the mixture, ice-water was added and the formed precipitatewas filtered, washed with water, dried and recrystallized fromformic acid to give compounds 3e-h or 10b
The synthetic route of 5334-28-1 has been constantly updated, and we look forward to future research findings.