In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.
Adding a certain compound to certain chemical reactions, such as: 141573-95-7, name is Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 141573-95-7, HPLC of Formula: C8H10F2N2O2
Example 9 (0339) (0340) At room temperature under a nitrogen atmosphere, 5.91 parts (purity: 95.9%, R isomers/S isomers=95.4/4.6) of (R)-1,1,3-trimethyl-4-aminoindane, 21.5 parts of tetrahydrofuran, and 1.29 parts (purity: 60%) of sodium hydride were mixed. The obtained mixture was heated and refluxed for 1 hour. The reaction liquid was cooled to room temperature. To the obtained solution was added dropwise a solution in which 6.13 parts (purity: 97.8%) of ethyl 1-methyl-3-difluoromethylpyrazole-4-carboxylate had been dissolved in 9.2 parts of tetrahydrofuran. The obtained mixture was heated in an oil bath at 90 C. and stirred for 8 hours while tetrahydrofuran was evaporated. At this time, tetrahydrofuran in the same amount of the evaporated tetrahydrofuran was added thereto freshly at times, such that the concentration of the reaction liquid became constant. The obtained mixture was cooled to room temperature and then 92.0 parts of toluene was added thereto. The obtained mixture was washed sequentially with 5% hydrochloric acid, a saturated sodium bicarbonate solution, and saturated physiological saline. The obtained organic layer was concentrated under reduced pressure to obtain 13.1 parts of (R)-(-)-N-(1,1,3-trimethylindan-4-yl)-1-methyl-3-difluoromethylpyrazole-4-carboxylic acid amide. The content of (R)-(-)-N-(1,1,3-trimethylindan-4-yl)-1-methyl-3-difluoromethylpyrazole-4-carboxylic acid amide was 64.8% (the yield with respect to ethyl 1-methyl-3-difluoromethylpyrazole-4-carboxylate of 86.4%). Further, the ratio of R isomers/S isomers of (R)-(-)-N-(1,1,3-trimethylindan-4-yl)-1-methyl-3-difluoromethylpyrazole-4-carboxylic acid amide was 95.4/4.6.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.