Share a compound : 4-Isopropyl-1H-pyrazol-5-amine

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151521-49-2, name is 4-Isopropyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H11N3

To a chilled solution of 4-isopropyl-1 H-pyrazol-5-amine (2.5 g, 20 mmol) in 20 ml DCM ethoxycarbonyl isothiocyanate (2.6 g, 20 mmol) dissolved in 10 ml DCM were added dropwise. The resulting suspension was further diluted with 30 ml DCM and stirred for 2 h. The product was collected, washed with DCM and dried. 2.0 g (7.8 mmol) of this raw material together with 3.2 g (23.4 mmol) were then refluxed in 15 ml MeCN for 2 h. After careful neutralization with acetic acid the solvent was removed in vacuo. The remaining solid was suspended in water. The product was collected, washed with water and dried to yield title compound (II) as colorless powder. 1 H-NMR (400MHz, d6-DMSO, 300K) delta 1 .14 (d, J = 6.8 Hz, 6H), 3.12 (h, J = 6.8 Hz, 1 H), 7.88 (s, 1 H), 12.60 (s, broad, 1 H), 13.34 (s, broad, 1 H); MS (ES) C8H10N4OS, requires 210.06, found 21 1 .3 (M+H)+.

According to the analysis of related databases, 151521-49-2, the application of this compound in the production field has become more and more popular.