Synthetic Route of 1126-00-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1126-00-7 name is 1-Phenylpyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 1-phenylpyrazole (2.0g, 13.87 mmoles) in TFA (l7mL) was stirred under a nitrogen atmosphere and treated with. hexamethylene tetramine (2.92 g, 20.81 mmoles). The reaction was refluxed overnight, and then cooled and poured into saturated sodium bicarbonate aqueous solution to adjust the pH to 7. The aqueous phase was extracted three times with ethyl acetate. The combined organic phases were washed with brine, dried overMgSO4, filtered and concentrated to 2.78 g of crude oil. Flash column chromatography on silica gel with a 40 gram Isco MPLC column using 10-20% EtOAc-Hexanes gradient provided 0.72 g of the title compound.1H NMR oe 9.98 (s, 1H), 8.44(s, 1H), 8.17 (s, 1H), 7.70 (m, 2H), 7.5 (m,2H), 7.4 (m,1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Phenylpyrazole, and friends who are interested can also refer to it.