Electric Literature of 66121-71-9, The chemical industry reduces the impact on the environment during synthesis 66121-71-9, name is 4-Cyano-1-methylpyrazole, I believe this compound will play a more active role in future production and life.
1-Methyl-1H-pyrazole-4-carbonitrile (18 gm, 0.168 moles) obtained in step 2, tn-nbutyl tin chloride (65 gm, 0.2 18 moles), sodium azide (14 gm, 0.20lmoles) were taken in toluene (180 ml). The reaction mixture.was stirred for 24 hours at 100-120C. The progress of the reaction was monitored by HPLC. The above reaction mixture was cooled to 10- 15C, to this added 10% ethanolic HCI solution (100 ml, pH= 1-2). The reaction mixturewas stirred for 1-1.5 hours at 10-15C, filtered off the inorganic salts, washed with ethanol (30 ml). The mother liquor and washings were collected and toluene and ethanol were recovered at 50-55C at reduced pressure. To the above residue at 20-25C, added diisopropyl ether (100 ml), stirred for 1-2 hours at 20-25C, filtered the solid, washed with diisopropyl ether (30 ml) and air dried the product, 5-(1-methyl-IH-pyrazol-4-yl)-2H-tetrazole at 60-65C.Drywt25gm1.4 w/w (99%)1.40w/wYieldTheoretical yield
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Cyano-1-methylpyrazole, other downstream synthetic routes, hurry up and to see.