Related Products of 13599-12-7, These common heterocyclic compound, 13599-12-7, name is Ethyl 3-phenyl-1H-pyrazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Ethyl 2,4-dioxo-4-phenylbutanoate (16b) (2.6 g, 9.1 mmol)Dissolved in 30mL of methanol, added 15mL lithium hydroxide monohydrate(0.5 g, 20.0 mmol) in water. The reaction was heated to 70 C until the hydrolysis was complete. Concentration under reduced pressure gave a solid suspension. 15 mL of water was added and the pH was adjusted to 3 with 1 N diluted hydrochloric acid. Filtering,The title compound 5-phenyl-1H-pyrazole-3-carboxylic acid (Intermediate 16) was obtained.Dark white solid (2.1 g, yield 89.5%).
Statistics shows that Ethyl 3-phenyl-1H-pyrazole-5-carboxylate is playing an increasingly important role. we look forward to future research findings about 13599-12-7.