Adding a certain compound to certain chemical reactions, such as: 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175137-46-9, name: 5-Cyclopropyl-1H-pyrazol-3-amine
A solution of S-cyclopropyl-lH-pyrazol-S-amine (1.9g, 16.0 mmol) in CH3CN (20 ml) was added dropwise to a solution of 2,6-dichloro-5-fluoronicotinonitrile (3.0 g, 16.0 mmol) and triethylamine (2.1 g, 20.0 mmol) in CH3CN (80 ml) at 25 C. The resulting solution was heated to 82 0C for 18 hrs, and then cooled to 25 0C. The resulted precipitate was collected by filtration and washed with CH3CN (100 ml) to give the title compound (3.2 g, 73%). MS:Calcd.: 277; Found: [M+H]+ 278.
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