Related Products of 110860-60-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110860-60-1, name is Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
(5) Synthesis of alpha-Type Crystal Morphology Azo Pigment Compound (2) (9.2 g) was dissolved in a mixed solution of 55 mL of acetic acid and 37 mL of propionic acid at room temperature, and the resulting solution was ice-cooled to lower the internal temperature to -3 C. A 40 mass % sulfuric acid solution of nitrosylsulfuric acid was added dropwise at an internal temperature of -3 C. to 4 C. over 10 minutes and after stirring at an internal temperature of 4 C. for 1 hour, 0.2 g of urea was added. Thereafter, the internal temperature was lowered to -3 C., and the mixture was further stirred for 10 minutes to obtain a diazonium salt solution. Separately, 10 g of Compound (3) was completely dissolved in 150 mL of acetone. This solution was cooled to an internal temperature of 17 C. and then added to the diazonium salt solution obtained above, at an internal temperature of -3 C. to 3 C. over 25 minutes. After the completion of addition, the mixture was stirred at 3 C. for 30 minutes, and the ice bath was removed. The temperature was raised to room temperature over 30 minutes, and the resulting solution was stirred at room temperature for 30 minutes. The obtained crystal was collected by filtration, spray-washed with 150 mL of acetone and further spray-washed with 100 mL of water. The obtained crystal was without drying suspended in 400 mL of water, and an aqueous 8 N potassium hydroxide solution was added to adjust the pH to 5.7. The system was stirred at room temperature for 20 minutes, and the obtained crystal was separated by filtration, thoroughly spray-washed with water and spray-washed with 80 mL of acetone. The obtained crystal was dried at room temperature for 12 hours.Crystal 1 obtained was suspended in 580 mL of acetone, and the suspension was stirred under reflux for 30 minutes and then cooled to room temperature over 10 minutes. The obtained crystal was separated by filtration and dried at 60 C. for 5 hours to obtain 17.1 g of an azo pigment composition containing an azo pigment represented by formula (1) having the crystal form of the present invention. Yield: 88.5%. The particle size of the obtained azo pigment was measured with an eye by using a transmission microscope (electron microscope JEM-1010, manufactured by JEOL Ltd.), as a result, the length in the long axis direction of the primary particle was about 15 mum.The obtained crystal was an alpha-type crystal morphology azo pigment shown in FIG. 1 or a tautomer thereof, having characteristic X-ray diffraction peaks at Bragg angles (2theta+/-0.2) of 7.6, 25.6 and 27.7 in the CuKalpha characteristic X-ray diffraction but not having a peak at 7.0 and 6.4 (alpha-Type Crystal Morphology Azo Pigment Composition 1).
The synthetic route of Methyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.