Introduction of a new synthetic route about Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate

The chemical industry reduces the impact on the environment during synthesis Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.

Reference of 400877-57-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 400877-57-8, name is Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

240 mg (1.30 mM) of the compound obtained in Preparative Example 7 was dissolved in 5 ml of methanol, to which 24 mg of 10% palladium/ EPO charcoal was added dropwise, and the resulting mixture was stirred under hydrogen pressure of 40 atm for 30 minutes. After the reaction was terminated, the resulting reaction solution was filtered through cellite, and distilled under reduced pressure, to obtain 191 mg (95%) of the title compound.1H NMR(SOOMHZ, CDCl3) delta 3.86(s, 3H), 3.92(s, 3H), 6.91(s, IH). Mass : 155(M+)

The chemical industry reduces the impact on the environment during synthesis Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate. I believe this compound will play a more active role in future production and life.