Reference of 637336-53-9,Some common heterocyclic compound, 637336-53-9, name is Methyl 4-amino-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H9N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Isoamyl nitrite (1.3 ml_, 9.67mmol) was added drop-wise to a suspension of methyl 4- amino-1-methyl-1 H-pyrazole-3-carboxylate (p130, 1 g, 6.45 mmol), CuBr2 (1.44 g, 6.45 mmol) and CuBr (924 mg, 6.45 mmol) in MeCN (25 ml_). The resulting mixture was stirred at 80 C for 2 hrs. After cooling to RT the volatiles were evaporated under vacuum and the residue was purified by FC on S1O2 column (eluting from cHex to 40% EtOAc ) to afford methyl 4-bromo- 1 -methyl- 1 H-pyrazole-3-carboxylate (p131 , 500 mg, y= 35 %) as brown solid. MS (/77/z): 220.9 [MH]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-amino-1-methyl-1H-pyrazole-3-carboxylate, its application will become more common.