Application of 5203-77-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
2.5 g (0.022 mol) of 1,3-dimethyl-5-hydroxypyrazole,40 mL of tetrahydrofuran was added to a three-necked flask,9.0 g of triethylamine (0.09 mol) was added with stirring.Ice bath control temperature of 5-10 ,A solution of 6.3 g (0.022 mol) of a solution of 2-methanesulfonyl-4-trifluoromethylbenzoyl chloride in tetrahydrofuran was added dropwise,Control the reaction temperature does not exceed 15 ,Drop finished,Remove the ice bath,The reaction was stirred at room temperature for 30 min,TLC detection reaction (ethyl acetate: petroleum ether = 4: 1, GF254, UV color)After the reaction is complete,2-methyl-2-hydroxypropanenitrile (0.2 g)Stirring slowly warming to 45-50 C reaction,TLC detection reaction (ethyl acetate: petroleum ether = 2: 1, GF254, UV color)After the reaction is complete,A solution of 5.5 g (0.023 mol) of tetrahydrofuran in 4-allyl-2-methoxyphenoxyacetyl chloride was added dropwise at room temperature,Control the temperature does not exceed 35 ,Drop at room temperature stirring 8hr,Add 50 mL of water to stir the crystals. The precipitated solid was collected by filtration and washed with 30% ethanol to give the title compound (7.2 g), yield: 57.8%
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Dimethyl-1H-pyrazol-5-ol, other downstream synthetic routes, hurry up and to see.