Application of 612511-81-6, These common heterocyclic compound, 612511-81-6, name is (1-Methyl-1H-pyrazol-3-yl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 5-bromo-2-chloro-3-nitropyridine (600 mg, 2.53 mmol) in CH3CN (12 mL) were added (1 -methyl-1 H-pyrazol-3-yl)methanamine (281 mg, 2.53 mmol) and N,N- diisopropylethylamine (0.530 mL, 3.03 mmol), and the reaction mixture was stirred at room temperature for 20 hours. The mixture was concentrated, and the resulting residue was washed with water and dried under vacuum to give the desired product (750 mg) as a pale yellow solid. LC-MS (ES) m/z = 312, 314 [M+H]+. NMR (400 MHz, CD3OD): delta 3.87 (s, 3H), 4.80 (d, J = 5.6 Hz, 2H), 6.25 (d, J = 2.3 Hz, 1 H), 7.52 (d, J = 2.3 Hz, 1 H), 8.51 (d, J = 2.3 Hz, 1 H), 8.63 (d, J = 2.3 Hz, 1 H).
The synthetic route of 612511-81-6 has been constantly updated, and we look forward to future research findings.