Electric Literature of 1572-10-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1572-10-7, name is 3-Amino-5-phenylpyrazole, This compound has unique chemical properties. The synthetic route is as follows.
3-Amino-5-phenyl pyrazole (477 mg) and ethyl 2-N,N-dimethylaminomethylene acetoacetate (556 mg) were dissolved in ethanol (10 ml) and stirred at 70C for 1.5 hours. The reaction mixture was added conc. hydrochloric acid (1 mg), and was stirred for additional 1 hour. The mixture was cooled to room temperature and concentrated under reduced pressure. Ethanol (10 ml) and 5 N aqueous sodium hydroxide solution (3 ml) were added to the residues and then stirred at 70C for 1 hour. After cooling to room temperature, water and ethyl acetate were added to the mixture. 2 N hydrochloric acid was added to the aqueous phase until it became acidic, and precipitated crystals were collected and washed with water and n-hexane to give 3f (463 mg, Y.: 61%) as yellow crystals.1H NMR: d 3.2 (3H, s), 7.4 (1H, s), 7.5 (3H, m), 8.1 (2H, d), 8.9 (1H, s), 13.6 (1H, brs); MS (m/z): 252 (M-H)-.
The chemical industry reduces the impact on the environment during synthesis 3-Amino-5-phenylpyrazole. I believe this compound will play a more active role in future production and life.