Application of 112029-98-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 112029-98-8, name is (1-Methyl-1H-pyrazol-4-yl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
[00775] Compound 58-a was synthesized according to Method A. Amide 58-b was synthesized from compound 58-a and 2-aminopyrazolo[ 1 ,5-a]pyrimidine-3-carboxylic acid according to Method D. Potassium teftbutoxide (0.25 mmol, 1.5 equiv was then suspended in anhydrous tetrahydrofuran (1 mL). A solution of (1-methyl- 1H-pyrazol-4-yl)methanol in tetrahydrofuran (1 mL) was then added and the mixture was heated to 40 ¡ãC. A solution of compound 58-b (0.17 mmol, 1.0 equiv) in tetrahydrofiaran (1 mL) was added and the temperature was increased to 60 ¡ãC. The reaction was heated for 45 mm after which there was no more starting material by LC/MS analysis. The mixture was cooled and poured into brine and then extracted with ethylacetate (2x). The combined organic layers were dried and concentrated onto silica gel (2g). The residue was then purified using flash silica gel chromatography (ISCO, Si-i 2g column, gradient of 0-10percent methanol, methylene chloride). The product containing fractions were then concentrated and further purified using reverse phase HPLC (Interchim-sunfire, gradient of 5- 50percent acetonitrile water, ammonium bicarbonate buffer) to provide compound 67 as the desired product. ESI-MS m/z: 535.4 [M+H]+.
The synthetic route of (1-Methyl-1H-pyrazol-4-yl)methanol has been constantly updated, and we look forward to future research findings.