Application of 4522-35-4, A common heterocyclic compound, 4522-35-4, name is 3-Iodo-1H-pyrazole, molecular formula is C3H3IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dichloromethane (5.0 mL) in 3-iodo-1H-pyrazole (1.03 mmol) solution, (4-(trifluoromethyl)phenyl)boronic acid (2.06 mmol), pyridine (5.15 mmol), copper (II)acetate (4.12 mmol) and triethylamine was added (3.09 mmol). The reaction mixturewas stirred at room temperature for two days. When the reaction is completed, afterremoving by filtration using Celite and the insoluble residue was filtered andconcentrated to a liquid. Purification of the crude residue by silica gel flash columnchromatography to produce a D1.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.