Reference of 3524-32-1, These common heterocyclic compound, 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A solution of equimolar amounts (9 mmol) of 1,3-dimethyl-1H-pyrazol-5-amine 3 [18] and substituted phenylacetylchlorides 7a-c in dry CHCl3 (30 mL) was refluxed for 5 h. After the first hour, triethylamine (1.25 mL, 9 mmol) was added in four portions (0.6, 0.3, 0.2, 0.15 mL respectively with intervals of 1 h between additions). The reaction mixture was evaporated under reduced pressure, the residue washed with cold water and crystallized from a suitable solvent.
The synthetic route of 3524-32-1 has been constantly updated, and we look forward to future research findings.