Reference of 50920-46-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50920-46-2, name is 1-Ethyl-5-methyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To an anhydrous DCM (5 mL) solution of 6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-amine (25 mg, 0.155 mmol) was added 1-ethyl-5-methyl-1H-pyrazole-3-carboxylic acid (26 mg, 0.171 mmol) followed by N1-((ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride (65.4 mg, 0.341 mmol). The reaction mixture was stirred for 3 h at room temperature. After completion of reaction, it was diluted with water and extracted with DCM. The organic layer was dried over anhydrous Na2SO4 and solvent was removed under vacuo. The crude product was purified by column chromatography. Yield: 30 mg (65percent). 1H NMR (CDCl3) delta 8.59 (s, 1H), 7.47-7.34 (m, 2H), 7.06 (d, J=7.7 Hz, 1H), 6.61 (d, J=0.7 Hz, 1H), 4.11 (q, J=7.3 Hz, 2H), 2.77 (dd, J=11.0, 9.0 Hz, 4H), 2.31 (d, J=0.6 Hz, 3H), 1.82 (d, J=5.5 Hz, 2H), 1.64 (q, J=5.3 Hz, 4H), 1.45 (t, J=7.3 Hz, 3H). HR-ESIMS: m/z 298.1841 [M+H]+ calcd for C18H24N3O, found 298.1917. HPLC Purity: 100percent (Retention Time=0.90 min).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Ethyl-5-methyl-1H-pyrazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.