106368-32-5, name is 5-Amino-1-(4-(methylsulfonyl)phenyl)-1H-pyrazole-4-carbonitrile, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 5-Amino-1-(4-(methylsulfonyl)phenyl)-1H-pyrazole-4-carbonitrile
A MIXTURE OF 5-AMINO-1- (4-METHANESULFONYL-PHENYL)-LH-PYRAZOLE-4-CARBONITRILE (540 mg), formic acid (10 mL) and 1 mL H2O was refluxed overnight at 102’C. After cooling to room temperature, a white precipitate was observed. The mixture was diluted with H20 (10 mL), filtered through a funnel and washed thoroughly with H20, CH30H, and diethyl ether. The white solid was collected and dried under vacuum to give a crude product (300 mg, 50% YIELD). H NMR (DMSO-D6, 4. 00 MHZ) 5 3. 26 (s, 3H), 8. 12 (d, 2H), 8. 29 (s, 1H), 8. 42 (d, 2H), 8. 44 (d, 1H), 12. 61 (s, 1H). LCMS : calculated C12HoN403S 290. 05, observed 291. 2 (MH+).
The synthetic route of 106368-32-5 has been constantly updated, and we look forward to future research findings.