2075-46-9, Name is 4-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, belongs to pyrazoles-derivatives compound, is a common compound. In a patnet, author is Nagaraja, Manju, once mentioned the new application about 2075-46-9, Recommanded Product: 4-Nitro-1H-pyrazole.
Synthesis of chalcone precursor via Cu(I) catalyzed 1,3-dipolar reaction of functionalized acetylene and pyrazole embedded dipole
A new class of functionalized pyrazole bearing 1,2,3-triazole has been synthesized via Cu(I) mediated 1,3-dipolar cycloaddition of pyrazole bearing azide with various aromatic/heteroaromatic bearing terminal dipolarophile (acetylene). Structures of the newly synthesized compounds were explicated by analytical and spectral analysis. All the newly synthesized compounds were evaluated for their in-vitro antibacterial and antioxidant activity. Among the synthesized compound, triazole bearing 2,5-thiazolidinone5b(20 +/- 0.70) and triazole bearing thiocarboamide5e(19 +/- 0.70) showed good antibacterial activity againstEscherichia coliandPseudomonas aeruginosa, respectively. The newly synthesized compounds further tested for their ability to bleach DPPH radical using DPPH scavenging assay. Among the synthesized compounds 1,2,3-triazole bearing 2,5-thiazolidinone5b(58.81%) exhibited good DPPH scavenging activity compared to the rest of the compounds. From the X-ray and Hirshfield analysis, it was observed that compound3, crystallizes in a triclinic crystal system with a P-1 space group. The major intercontacts present in these molecules are H horizontal ellipsis H (39.7%), C horizontal ellipsis H (23.9%), N horizontal ellipsis H (20.3%).
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics