A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Quality Control of Phenylbutazone, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50-33-9, Name is Phenylbutazone, molecular formula is C19H20N2O2. In an article, author is Li, Dongying,once mentioned of 50-33-9.
K2CO3-Promoted Pyrazoles Synthesis from 1,3-Dipolar Cycloaddition ofN-Tosylhydrazones with Acetylene Gas
1,3-Dipolar cycloaddition ofN-tosylhydrazones with acetylene gas on balloon was investigated. Bases and solvents were screened and K(2)CO(3)was verified to be an efficient base to promote this process. DMSO gave the better result in the reaction ofN-tosylhydrazones derived from aldehyde, and NMP was a better suitable solvent in the reaction of ketoneN-tosylhydrazones. And a series of pyrazoles were provided in mediate to good yields. This process was easy to handle and suitable to the industrial application.
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics