1453-58-3, Name is 3-Methylpyrazole, molecular formula is C4H6N2, belongs to pyrazoles-derivatives compound, is a common compound. In a patnet, author is Zhang, Bo, once mentioned the new application about 1453-58-3, Recommanded Product: 3-Methylpyrazole.
Discovery of novel aminophosphonate derivatives containing pyrazole moiety as potential selective COX-2 inhibitors
Cyclooxygenase is critical for maintaining physiological functions, whereas overexpression of COX-2 was closely implicated in various cancers. In this study, a series of novel aminophosphonate derivatives containing pyrazole moiety were synthesized with their anti-cancer activity evaluated. In vitro assays of the target compounds showed that Z21 displayed excellent COX-2 inhibitory activity against COX-2 (IC50 = 0.22 +/- 0.04 mu M) and anti-proliferative activity against MCF-7 cell (IC50 = 4.37 +/- 0.49 mu M). The apoptosis induction of compound Z21 was confirmed by flow cytometry and polymerase chain reaction. Further investigation demonstrated that compound Z21 induced apoptosis of MCF-7 cells through a mitochondrion-dependent pathway and involved cell-cycle arrest in G2 phase. Overall, these results provided some new insights into the design of therapeutic drugs for COX-2 inhibitors and indicated the connection between selective COX-2 inhibition and the anti-tumor activity.
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics