Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Quality Control of Ethyl 4-pyrazolecarboxylate, 37622-90-5, Name is Ethyl 4-pyrazolecarboxylate, SMILES is C1=N[NH]C=C1C(OCC)=O, belongs to pyrazoles-derivatives compound. In a document, author is Bhirud, J. D., introduce the new discover.
Oxidative Cyclization of Chalcones in the Presence of Sulfamic Acid as Catalyst. Synthesis, Biological Activity, and Thermal Properties of 1,3,5-Trisubstituted Pyrazoles
1-Aroyl-3,5-diaryl-1H-pyrazoles were synthesized by oxidative cyclization of chalcones with benzohydrazide and 4-nitrobenzohydrazide using sulfamic acid as a catalyst. The corresponding chalcones were prepared by condensation of aromatic aldehydes with acetophenones in PEG-400 in the presence of potassium hydroxide. Some representative features of the proposed procedure include exceptional regioselectivity, comparatively short reaction time, operational simplicity, and no need of external oxidant. The synthesized pyrazole derivatives were screened as antibacterial agents against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Salmonella typhi by the agar well diffusion method. Attempts were made to compute specific heat capacity of the synthesized pyrazole derivatives as a function of temperature using TGA-DSC in order to avail thermodynamic database for these biologically relevant heterocycles.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 37622-90-5. Quality Control of Ethyl 4-pyrazolecarboxylate.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics