Chemistry is an experimental science, Safety of 1H-Pyrazole-4-carbaldehyde, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 35344-95-7, Name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, belongs to pyrazoles-derivatives compound. In a document, author is Dong, Cuntao.
Synthesis of pyrazole-4-carboxamides as potential fungicide candidates
A series of novel pyrazole-4-carboxamides were rationally designed, synthesized, and their structures were characterized by(1)H NMR,C-13 NMR and HRMS. Preliminary bioassay showed that four compounds 8g, 8j, 8o and 8s exhibited more than 90% and even completed inhibition againstAlternaria solaniat 100 mu g/mL; and 8d displayed 100% inhibition against Fusarium oxysporumat the same concentration. Moreover, 8j exhibited good in vitro fungicidal activity against A. solani with EC50 value of 3.06 mu g/mL, and it also displayed completed in vivo protective antifungal activity against A. solanion tomato at 10 mg/L, as boscalid did. The molecular docking results indicated that 8j exhibited the high affinity with SDH protein by H-bond and pi-pi stacking interactions, which may explain the reasons for its good activities. These data support that compound 8 jcould be used as a fungicide candidate for further study. Graphic abstract A practical method for the synthesis of pyrazole-4-carboxamides were provided and evaluation of their antifungal activities. [GRAPHICS] .
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 35344-95-7. Safety of 1H-Pyrazole-4-carbaldehyde.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics