Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 330792-70-6, Name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, molecular formula is C16H12N4O, belongs to pyrazoles-derivatives compound, is a common compound. In a patnet, author is Qi, Hong-Liang, once mentioned the new application about 330792-70-6, Quality Control of 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile.
A robust Co(II)-organic framework for photocatalytic dye degradation and treatment effect on the neonatal sepsis
A stable Co(II)-based metal-organic framework (MOF) was constructed by applying a dual ligand strategy. The ultra-stable Co(II) MOF, [Co(H(3)tpb)(Hbtc)](n) (1), was obtained by hydrothermal reaction of a novel trimer pyrazole ligand H(3)tpb and a classic carboxylic ligand H(3)btc (H(3)tpb = 1,3,5-tris (pyrazolyl) benzene, H(3)btc = 1,3,5-benzoic acid). In addition, complex 1 shows photocatalytic activity for the degradation of the dyes methylene blue (MB) and methyl orange (MO) under UV light. About 83.8% MB and 75.3% MO could be removed within 150 min. Serial experiments were performed to evaluate the biological activity of this compound in neonatal sepsis and explore its related mechanism. The results of the ELISA showed that the compound could reduce the releasing of the inflammatory cytokines in a dose-dependent manner. Besides, the compound could also reduce the relative expression levels of the gram-positive bacterial virulence. Simulations based on the molecular docking found that the complex could form multiple hydrogen bonds with several residues in the domain pocket. [GRAPHICS] .
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics