Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1985-46-2, Name is N2,N2-Dimethyl-1,3,5-triazine-2,4,6-triamine, SMILES is NC1=NC(N)=NC(N(C)C)=N1, belongs to pyrazoles-derivatives compound. In a document, author is Wu, Zhibing, introduce the new discover, Recommanded Product: 1985-46-2.
Synthesis, Biological Evaluation, and 3D-QSAR Studies of N-(Substituted pyridine-4-yl)-1-(substituted phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxamide Derivatives as Potential Succinate Dehydrogenase Inhibitors
A series of new fungicides that can inhibit the succinate dehydrogenase (SDH) was classified and named as SDH inhibitors by the Fungicide Resistance Action Committee in 2009. To develop more potential SDH inhibitors, we designed and synthesized a novel series of N-(substituted pyridine-4-yl)-1-(substituted phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxamide derivatives, 4a-4i, namely, 5a-5h, 6a-6h, and 7a-7j. The bioassay results demonstrated that some title compounds exhibited excellent antifungal activity against four tested phytopathogenic fungi (Gibberella zea, Fusarium oxysporum, Cytospora mandshurica, and Phytophthora infestans). The EC50 values were 1.8 mu g/mL for 7a against G. zeae, 1.5 and 3.6 mu g/mL for 7c against F. oxysporum and C mandshurica, respectively, and 6.8 mu g/mL for 7f against P. infestans. The SDH enzymatic activity testing revealed that the IC so values of 4c, 5f, 7f, and penthiopyrad were 12.5, 135.3, 6.9, and 223.9 mu g/mL, respectively. The molecular docking results of this series of title compounds with SDH model demonstrated that the compounds could completely locate inside of the pocket, the body fragment formed H bonds, and the phenyl ring showed a pi-pi interaction with Arg59, suggesting that these novel 5-trifluoromethyl-pyrazole-4-carboxamide derivatives might target SDH. These results could provide a benchmark for understanding the antifungal activity against the phytopathogenic fungus P. infestans and prompt us to discover more potent SDH inhibitors.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1985-46-2 is helpful to your research. Recommanded Product: 1985-46-2.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics